After you receive your prescription, your healthcare provider will file a ZILBRYSQ Start Form to begin the ONWARD enrollment process on your behalf. During this process, you’ll get your first call from your ONWARD Care Coordinator. Separately but at the same time, a Benefits Investigation may be initiated.

Benefits Investigation (BI) is an important step to determine the anticipated out-of-pocket cost of your medication and its administration. This process is initiated by specialty pharmacy PANTHERx RARE in coordination with your insurance provider.

Once enrolled, your dedicated ONWARD Care Coordinator will work with you to understand your personal situation and explain potential financial assistance options available, even if you’re uninsured.

ONWARD^TM is a personalized support experience built to help you through every step of your prescribed UCB treatment. With ONWARD, you’ll be paired with your own dedicated Care Coordinator who will provide support based on your unique needs.

There are three ways to be enrolled in ONWARD:

• Ask your healthcare provider to sign you up.
• Download a Start Form and bring it to your healthcare provider.
• Call  1-884-ONWARD-1 (1-844-669-2731) today.

After enrolling in ONWARD, you’ll be contacted by your dedicated ONWARD Care Coordinator.

Care Coordinators are:

• Medically trained professionals, including nurses and pharmacists
• Professionally trained to understand your disease and treatment
• Dedicated to your treatment experience

^*ONWARD Care Coordinators do not provide medical advice and will refer you to your healthcare professional for any questions related to your treatment plan.

After you enroll, your Care Coordinator will call you directly to begin providing personalized support and resources.

You and your caregivers can reach your Care Coordinator at the number provided or
844-ONWARD-1 (844-669-2731), Monday – Friday from 8AM to 8PM ET.

Before you can receive ZILBRYSQ, you will need to work with your healthcare provider to receive all required vaccinations. Your healthcare provider will ensure you are up to date with two types of meningococcal vaccines.

A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program that the U.S. Food and Drug Administration (FDA) requires for certain medications. ZILBRYSQ is only available through a program called the ZILBRYSQ REMS. Before you can receive ZILBRYSQ, your healthcare provider must:

• enroll in the ZILBRYSQ REMS.
• counsel you about the risk of meningococcal infection.
• give you the Patient Guide, including information about the signs and symptoms of meningococcal infection.
• give you a Patient Safety Card about your risk of meningococcal infection.
• make sure that you are vaccinated with two types of meningococcal vaccines and, if needed, get revaccinated with the meningococcal vaccines. Ask your healthcare provider if you are not sure if you need to be revaccinated.

A specialty pharmacy is a type of pharmacy that focuses on providing medications for complex, chronic or rare conditions.

ZILBRYSQ is delivered via specialty pharmacy, PANTHERx RARE, directly to your home. Your Care Coordinator can help you get in touch with PANTHERx, as needed.

ZILBRYSQ is given as an injection under the skin (for subcutaneous use) in a prefilled syringe. Use ZILBRYSQ exactly as prescribed by your healthcare provider.

• After proper training on how to prepare and inject your ZILBRYSQ syringe, you or your caregiver will inject ZILBRYSQ daily. Your healthcare provider will decide the total daily dose depending on your body weight.
• Each prefilled syringe is for single-use only. Throw away the prefilled syringe after each use. Do not reuse.
• Your daily dose of ZILBRYSQ should be injected at about the same time each day.
• If you miss your ZILBRYSQ dose, inject a dose as soon as possible. Then, inject your next dose at your regular scheduled time. Do not inject more than 1 dose each day. Call your healthcare provider if you are not sure what to do.

You can also review this video for refresher training.

Your healthcare provider will show you initially and your Care Coordinator can provide refresher training.

Contact PANTHERx at 1-833-418-7760 for any questions related to the syringe and medication. For
general questions or help, please call your healthcare provider or UCBCares at 1-844-599-CARE (2273).

ZILBRYSQ prefilled syringes may be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) until the expiration date on the carton. Do not freeze ZILBRYSQ. Keep the prefilled syringes in the original carton until ready for use to protect from light.

ZILBRYSQ prefilled syringes may be stored at room temperature up to 86°F (30°C) in the original carton to protect them from light for a single period of up to 3 months. Write the date you removed the prefilled syringes from the refrigerator in the space provided on the carton. After ZILBRYSQ prefilled syringes have been stored at room temperature, do not place them back in the refrigerator and throw them away if not used within the 3- month period or if the expiration date has passed, whichever occurs first. Throw away any unused portion.

The daily dose should be injected at approximately the same time each day. If a dose is missed, inject the dose as soon as possible. Thereafter, inject the next dose at the regular scheduled time. Do not inject more than 1 dose per day.

ZILBRYSQ may cause serious side effects, including inflammation of the pancreas (pancreatitis) and other pancreatic problems.

Call your healthcare provider right away if you have pain in your stomach area (abdomen) that will not go away. Your healthcare provider will tell you if you should stop using ZILBRYSQ. The pain may be severe or felt going from your abdomen to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

The most common side effects of ZILBRYSQ include:

• injection site reactions
• upper respiratory tract infections
• diarrhea

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the possible side effects of ZILBRYSQ. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tracking your symptoms allows you to see how you are responding to treatment over time. By tracking and communicating your MG-ADL results to your healthcare provider, your healthcare team can make sure you’re on the right treatment path.